Methyl iodide → HCID 86740701, compound

HRID 1380035Notes

Reaction equation

HRID 1380035 reaction equation
[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[N:11]=[CH:10][N:9]([CH2:15][O:16][CH:17]([CH2:20][OH:21])[CH2:18][OH:19])[C:8]=2[N:7]=[C:5]1[NH2:6])[CH2:2][CH3:3].C[I:23].[I-].[CH2:25](N1C(=O)C2N(C)CN(COC(O)CCO)C=2N=C1N)CC>CN(C=O)C>[I-:23].[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[N:11]([CH3:25])[CH2:10][N:9]([CH2:15][O:16][CH:17]([CH2:20][OH:21])[CH2:18][OH:19])[C:8]=2[N:7]=[C:5]1[NH2:6])[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 70456556HCID 70456556, compoundHCID 86740702HCID 86740702, compound

Product 1

HCID 86740701HCID 86740701, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the method of Example 5, using 1-propyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine and methyl iodide in DMF at 60° C. overnight, prepare 1-propyl-7-methyl-9(1,3-dihydroxypropoxymethyl)guanine iodide.

Workup

  1. customat 60° C.
  2. customovernight

Sources & evidence

ORD record
ord-60760d36e739498e90fa7c1f71d3ff5c
Source dataset
uspto-grants-1986_04
Patent number
US04579849

Reaction notes

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