L-Cysteine hydrochloride monohydrate → HCID 57006158, compound

HRID 1380040Notes

Reaction equation

HRID 1380040 reaction equation
COC([S:5][CH2:6][CH2:7][CH2:8][N:9]1[CH:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][NH:11][C:10]1=[O:20])=O.O.Cl.[NH2:23][C@H:24]([C:27]([OH:29])=[O:28])[CH2:25][SH:26]>CO>[O:20]=[C:10]1[N:9]([CH2:8][CH2:7][CH2:6][S:5][S:26][CH2:25][C@@H:24]([C:27]([OH:29])=[O:28])[NH2:23])[CH:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:12][NH:11]1

Participants

4

Reactant 2

HCID 23462L-Cysteine hydrochloride monohydrateHCID 13604348HCID 13604348, compound

Product 1

HCID 57006158HCID 57006158, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3.3 g of methyl-[3-(2-oxo-4-phenyl-3-imidazolidinyl)propylthio]formate and 1.8 g of L-cysteine hydrochloride hydrate in 80 ml of methanol is refluxed under nitrogen for three hours. The solvent is removed in vacuo and the residue triturated with ether yielding a hygroscopic solid. The product is further purified by conversion to its 4-methyl benzene sulfonic acid salt, m.p. 172°-178° C.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue triturated with ether yielding a hygroscopic solid
  3. customThe product is further purified by conversion to its 4-methyl benzene sulfonic acid salt, m.p. 172°-178° C.

Sources & evidence

ORD record
ord-c7791bebf7cd4efdb447e3d89b1638dd
Source dataset
uspto-grants-1986_04
Patent number
US04579857

Reaction notes

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