Lithium aluminum hydride → HCID 20241760, compound

HRID 1380045Notes

Reaction equation

HRID 1380045 reaction equation
[AlH4-].[Li+].[O:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH:4]1[CH:13]([N:16]1[CH2:21][CH2:20][CH:19]([C:22]([NH2:24])=O)[CH2:18][CH2:17]1)[CH2:14][OH:15]>O1CCCC1>[O:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH:4]1[CH:13]([N:16]1[CH2:17][CH2:18][CH:19]([CH2:22][NH2:24])[CH2:20][CH2:21]1)[CH2:14][OH:15]

Participants

4

Reactant 2

HCID 28112Lithium aluminum hydrideHCID 20241766HCID 20241766, compound

Product 1

HCID 20241760HCID 20241760, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 30 g lithium aluminohydride in 1000 ml tetrahydrofuran is prepared under stirring and at room temperature. To this suspension 66 g of previously ground 1-[1-(2,3-dihydro[4H]1,4-benzodioxin-2 yl)2-hydroxy ethyl]piperidine 4-carboxamide are added portionwise.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-8475fba2adac4b05b57f29f042583fe0
Source dataset
uspto-grants-1986_04
Patent number
US04579845

Reaction notes

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