反应详情

A 2.0 g portion of hydroxylamine hydrochloride was dissolved in 12 ml of water and 8 ml of 5N sodium hydroxide was added. A 1.0 g portion of 3-(difluoromethoxy)benzaldehyde was added followed by enough ethanol to give a solution. After 10 minutes of reflux, the reaction mixture was concentrated in vacuo and the residue taken up in 10 ml of water. The pH was adjusted to 4 with hydrochloric acid, then the mixture was extracted with chloroform. The organic phase was dried over sodium sulfate and concentrated, giving the desired compound as an oil.

1. customto give a solution
2. temperatureAfter 10 minutes of reflux
3. concentrationthe reaction mixture was concentrated in vacuo
4. extractionthe mixture was extracted with chloroform
5. dry with materialThe organic phase was dried over sodium sulfate
6. concentrationconcentrated