反应详情

A 23.91 g portion of 2-(3-tolyl)-4-pyrimidinol was mixed with 400 ml of phosphorous oxychloride in a one liter round bottom flask, under a drying tube and heated on a steam bath overnight. The mixture was allowed to cool and then poured over 2 liters of ice. The resulting solid was collected, washed with 50 ml of ether, dried and recrystallized from 100 ml of ethanol, giving 16.23 g of the desired intermediate, mp 74°-75° C.

1. temperatureheated on a steam bath overnight
2. temperatureto cool
3. customThe resulting solid was collected
4. washwashed with 50 ml of ether
5. customdried
6. customrecrystallized from 100 ml of ethanol