Hydrazine hydrate (1:1) → HCID 20241988, compound

HRID 1380060Notes

Reaction equation

HRID 1380060 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([I:14])[CH:9]=2)[N:3]=1.O.[NH2:16][NH2:17]>O>[NH:16]([C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([I:14])[CH:9]=2)[N:3]=1)[NH2:17]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20241991HCID 20241991, compound

Product 1

HCID 20241988HCID 20241988, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 20.7 g of 4-chloro-2-(3-iodophenyl)pyrimidine, 140 ml of water and 80 ml of hydrazine hydrate was heated on a steam bath to produce solution, then refluxed 1/2 hour and allowed to cool overnight. The resulting crystals were collected, washed with methanol:water (1:1) and dried, giving 4-hydrazino-2-(3-iodophenyl)pyrimidine.

Workup

  1. temperaturewas heated on a steam bath
  2. customto produce solution
  3. temperaturerefluxed 1/2 hour
  4. temperatureto cool overnight
  5. customThe resulting crystals were collected
  6. washwashed with methanol:water (1:1)
  7. customdried

Sources & evidence

ORD record
ord-739b2aef654640418e5e9147c9d27bf5
Source dataset
uspto-grants-1986_04
Patent number
US04579848

Reaction notes

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