(+-)-p-Methoxyamphetamine → HCID 20026878, compound

Participants

Reaction Steps

10.84 g of 8-benzyloxy-5-(dihydroxyacetyl)carbostyril 1/3 hydrate and 5.66 g of N-(2-(p-methoxyphenyl)-1-methylethyl)amine are dissolved in 100 ml of dimethylsulfoxide, and the solution is stirred at room temperature for one hour. The mixture is extracted with chloroform, and the extract is washed with water and a saturated sodium chloride solution, successively. The chloroform solution is dried and concentrated under reduced pressure to remove solvent. The residue is crystallized with a mixture of ethyl acetate and n-hexane, and crystalline precipitates are collected by filtration. 13 g of 8-benzyloxy-5-{1-oxo-2-[N-(2-(p-methoxyphenyl)-1-methylethyl)imino]ethyl}carbostyril are obtained as yellow solid. Yield: 87.6%

Provenance & Evidence