反应详情

A mixture of 1-(3-chloropropyl)-3-n-hexylurea (2.21 g; 10 mmole), 1-[3-(4-chlorophenyl)propyl]piperazine (2.39 g; 10 mmole), triethylamine (1.01 g; 10 mmole) and alcohol (25 ml) was refluxed for 18 hours. The cooled reaction mixture was diluted with ether and washed with water, dried (sodium sulfate) and concentrated in vacuo. The resulting yellow viscous oil was purified on a silica gel column (methylene chloride/methanol; 93:7) and precipitated with ethereal hydrochloric acid to provide the title compound (1.6 g; 38% yield) as colorless crystals, m.p. 213°-216° C.

1. temperaturewas refluxed for 18 hours
2. customThe cooled reaction mixture
3. washwashed with water
4. dry with materialdried (sodium sulfate)
5. concentrationconcentrated in vacuo
6. customThe resulting yellow viscous oil was purified on a silica gel column (methylene chloride/methanol; 93:7)
7. customprecipitated with ethereal hydrochloric acid