HCID 23326372, compound → HCID 19017775, compound

HRID 1380281Notes

Reaction equation

HRID 1380281 reaction equation
C([N:8]1[C:12]2[C:13]([O:19][CH3:20])=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:11]=2[N:10]=[C:9]1[NH2:21])C1C=CC=CC=1>[Pd]>[NH2:21][C:9]1[NH:10][C:11]2[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([O:19][CH3:20])[C:12]=2[N:8]=1

Participants

3

Reactant 1

HCID 23326372HCID 23326372, compound

Product 1

HCID 19017775HCID 19017775, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1-Benzyl-2-amino-4,7-dimethoxybenzimidazole (17.85 g, 0.06 mole) is hydrogenated in the presence of palladium on carbon catalyst (10%) at 50 psi for about twelve hours. After filtration the methanol is removed in vacuo and the residue dissolved in boiling water and treated with decolorizing charcoal. The suspension is filtered into 1N NaOH, giving a white precipitate of 2-amino-4,7-dimethoxybenzimidazole. The amorphous white powder melts at 251°-253° C.

Workup

  1. filtrationAfter filtration the methanol
  2. customis removed in vacuo
  3. dissolutionthe residue dissolved
  4. additiontreated with decolorizing charcoal
  5. filtrationThe suspension is filtered into 1N NaOH

Sources & evidence

ORD record
ord-7ab9f746c59b47e3b66780f35e84edb4
Source dataset
uspto-grants-1986_04
Patent number
US04581349

Reaction notes

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