反应详情

温度

70 °C

(±)-1'-(4-Bromo-2-fluorobenzyl)-7'-chloro-spiro[imidazoline-4,3'-indoline]-2,2',5'-trione (64.4 g.) was dissolved in a 0.253 M solution of (-)-N,N,N-trimethyl-(1-phenylethyl)ammonium hydroxide in methanol (581 ml.). The solution was filtered and the filtrate was evaporated. The residue was dissolved in 2-methoxyethanol (132 ml.). The solution was warmed to 70° C. and then diluted with 1,2-dimethoxyethane (440 ml.) previously warmed to 70° C. The clear solution was stored at 0° C. for 48 hours and the crystals of the quaternary ammonium salt were collected by filtration [27 g.; [α]D23 +21.1°, c. 0.93, MeOH)]. This product was recrystallised from 2-methoxyethanol (55.3 ml.) and 1,2-dimethoxyethane (184 ml.) to give crystals [20 g.; [α]D23 +22° (c.1.11, MeOH)]. A third recrystallisation gave crystals [15.8 g.; [α]D23 +21.9° (c.1.12 MeOH)]. The crystalline salt (15.8 g.) thus obtained was dissolved in methanol (50 ml.) and treated with 0.25 M aqueous hydrochloric acid (105 ml.). The solution was chilled at 0° C. overnight and the solid removed by filtration, washed with water and dried over phosphorus pentoxide under vacuum to give the (+)-enantiomer of 1'-[4-bromo-2-fluorobenzyl]-7'-chloro-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (9.1 g.), m.p. 260°-262° C., [α]D23 +17.9° (c. 0.89, MeOH).

1. filtrationThe solution was filtered
2. customthe filtrate was evaporated
3. dissolutionThe residue was dissolved in 2-methoxyethanol (132 ml.)
4. additiondiluted with 1,2-dimethoxyethane (440 ml.)
5. temperaturepreviously warmed to 70° C
6. filtrationthe crystals of the quaternary ammonium salt were collected by filtration [27 g
7. customThis product was recrystallised from 2-methoxyethanol (55.3 ml.) and 1,2-dimethoxyethane (184 ml.)
8. customto give crystals [20 g.; [α]D23 +22° (c.1.11, MeOH)]
9. customA third recrystallisation
10. customgave crystals [15.8 g.; [α]D23 +21.9° (c.1.12 MeOH)]
11. customThe crystalline salt (15.8 g.) thus obtained
12. temperatureThe solution was chilled at 0° C. overnight
13. customthe solid removed by filtration
14. washwashed with water
15. dry with materialdried over phosphorus pentoxide under vacuum