Methane → 6-[4-(3-methylthioureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one

Participants

Role	Name	HCID	Charge
Reactant	Methane	HCID 297	—
Reactant	Methyl isothiocyanate	HCID 11167	—
Reactant	6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one	HCID 13386033	—
Solvent	Dimethylformamide	HCID 6228	—
Product	6-[4-(3-methylthioureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one	HCID 54466127	99.4%

Reaction Conditions

Temperature	110 °C

Reaction Steps

Methyl isothiocyanate (0.788 g) was added to a solution of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2 g) in N,N-dimethylformamide (20 ml) and the mixture was stirred for 4 hours at 110° C. After cooling, the mixture was treated with activated charcoal and evaporated in vacuo. The residual solid was washed with water and dried to give 6-[4-(3-methylthioureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2.7 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04581356
Source dataset	uspto-grants-1986_04
ORD ID	ord-51e9de1a728b4845a55c59fdfaf8b748
Source note	uspto-grants-1986_04