1-(2-Hydroxyethyl)piperazine → HCID 23326470, compound

HRID 1380322Notes

Reaction equation

HRID 1380322 reaction equation
C(O[C:4]([CH2:6][N:7]1[C:11]2[CH:12]=[C:13]([C:16]3[CH:17]([CH3:23])[NH:18][C:19](=[O:22])[NH:20][N:21]=3)[CH:14]=[CH:15][C:10]=2[S:9][C:8]1=[O:24])=[O:5])C.[OH:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[OH:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][N:31]([C:4]([CH2:6][N:7]2[C:11]3[CH:12]=[C:13]([C:16]4[CH:17]([CH3:23])[NH:18][C:19](=[O:22])[NH:20][N:21]=4)[CH:14]=[CH:15][C:10]=3[S:9][C:8]2=[O:24])=[O:5])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 23326477HCID 23326477, compound

Product 1

HCID 23326470HCID 23326470, compoundYield 72.5%

Conditions

Temperature
120 °C

Procedure

A mixture of the object compound of Example 21 (1.0 g) and 1-(2-hydroxyethyl)piperazine (1.2 g) was stirred for 4 hours at 120° C. After cooling, the reaction mixture was chromatographed on silica gel (45 g) by eluting with a mixture of chloroform and methanol (9:1) to give 0.9 g of 3-[4-(2-hydroxyethyl)piperazin-1-yl-carbonylmethyl]-5-(5-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)benzothiazolin-2-one.

Workup

  1. temperatureAfter cooling
  2. customthe reaction mixture was chromatographed on silica gel (45 g)
  3. washby eluting with a mixture of chloroform and methanol (9:1)

Sources & evidence

ORD record
ord-7a3d6f88de714c3f8679e68353237f11
Source dataset
uspto-grants-1986_04
Patent number
US04581356

Reaction notes

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