1-(2-Hydroxyethyl)piperazine → HCID 23326470, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the object compound of Example 21 (1.0 g) and 1-(2-hydroxyethyl)piperazine (1.2 g) was stirred for 4 hours at 120° C. After cooling, the reaction mixture was chromatographed on silica gel (45 g) by eluting with a mixture of chloroform and methanol (9:1) to give 0.9 g of 3-[4-(2-hydroxyethyl)piperazin-1-yl-carbonylmethyl]-5-(5-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)benzothiazolin-2-one.

Provenance & Evidence