反应详情

Thionyl chloride (11.5 ml; 158 mmoles) was added to α-trifluoromethylacrylic acid (19.7 g; 141 mmoles), and the mixture was heated under reflux for 22 hours. Distillation of the reaction mixture under atmospheric pressure gave 14.7 g (yield:66%) of α-trifluoromethylacryloyl chloride, B.p. 89°-90° C.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 22 hours
3. distillationDistillation of the reaction mixture under atmospheric pressure