Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylurea | HCID 10853 | — |
| Reactant | 2-(Trifluoromethyl)acrylic acid | HCID 587694 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13313789 | HCID 13313789 | 76% |
Reaction Steps
A mixture of α-trifluoromethylacrylic acid (700 mg; 5.0 mmole) and benzylurea (841 mg; 5.6 mmoles) in DMF (3 ml) was heated at 90° C. with stirring for 28 hours. DMF was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetatechloroform to give 1.10 g (yield: 76%) of 1-benzyl-3-(2-hydroxycarbonyl-3,3,3-trifluoropropyl)urea. m.p.: 183°-183.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04581452 |
|---|
| Source dataset | uspto-grants-1986_04 |
|---|
| ORD ID | ord-d40143427dd84fe0a5438b377f6cfbaa |
|---|
| Source note | uspto-grants-1986_04 |
|---|
