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HRID1380449

反应详情

EQUATION

反应方程式

HRID 1380449 的结构方程式

REACTANTS

反应物

5
结构：O=C([O-])C(F)(F)F
HCID84468

Trifluoroacetate

C2F3O2-

结构：CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.F[P-](F)(F)(F)(F)F
HCID151348

Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate

C12H22F6N6OP2

结构：C[C@H](NC(=O)OCc1ccccc1)C(=O)O
HCID736104

N-Benzyloxycarbonyl-L-alanine

C11H13NO4

结构：ClCCl.O=C(O)C(F)(F)F
HCID21863450

未命名化合物

结构：CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(N)=O
HCID178446001

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)[C@H](C)NC(=O)OCc1ccccc1)C(N)=O
HCID178445999

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

From 715 g of trifluoroacetate of E-Arg(NO2)Ala-Arg(NO2)-Leu-NH2 in solution in 4 l of DMF and 233 g of Z-Ala-OH and 500 g of BOP employing the same technique as the one described in I-2 (and without treatment in that case by TFA-CH2Cl2), 612 g of Z-Ala-Arg(NO2)-Ala-Arg(NO2)Leu-NH2 (76%) are obtained, after recrystallization in the DMF-ether mixture, in the form of a white pulverulent solid, monitored by TLC and NMR.

WORKUP

后处理

  1. customare obtained
  2. customafter recrystallization in the DMF-ether mixture