Trifluoroacetic acid → HCID 131714605, compound

HRID 1380457Notes

Reaction equation

HRID 1380457 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:22]([NH:24][C@H:25]([C:27]([O:29][CH3:30])=[O:28])[CH3:26])=[O:23])[CH2:20][OH:21])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].C(O)(C(F)(F)F)=O>ClCCl>[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:16]([NH:18][C@H:19]([C:22]([NH:24][C@H:25]([C:27]([O:29][CH3:30])=[O:28])[CH3:26])=[O:23])[CH2:20][OH:21])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131714606HCID 131714606, compound

Product 1

HCID 131714605HCID 131714605, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

10.3 g (18.8 mM) of Boc-Gln-Leu-Ser-Ala-OCH3 are stirred for 35 mins. in 100 ml of dichloromethane containing 100 ml of TFA. The reaction medium is concentrated in vacuo to about 50 ml and poured over 300 ml of ether. The precipitate is drained, washed with ether and dried in vacuo.

Workup

  1. concentrationThe reaction medium is concentrated in vacuo to about 50 ml
  2. additionpoured over 300 ml of ether
  3. washwashed with ether
  4. customdried in vacuo

Sources & evidence

ORD record
ord-ce3f3555dfc14d239651c6d8cc77052e
Source dataset
uspto-grants-1986_04
Patent number
US04581168

Reaction notes

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