Ethanol → HCID 23325158, compound

HRID 1380466Notes

Reaction equation

HRID 1380466 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][CH:5]([NH:6][C:7](=[O:12])[CH2:8][O:9][CH2:10][CH3:11])[C:4](OCC)([N+:15]([O-])=O)[CH:3]=1.[H][H].[CH2:23]([OH:25])[CH3:24]>[Ni]>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([NH:6][C:7](=[O:12])[CH:8]([O:9][CH2:10][CH3:11])[O:25][CH2:23][CH3:24])=[C:4]([NH2:15])[CH:3]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 23325179HCID 23325179, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23325158HCID 23325158, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

0.8 g of Raney-nickel are placed in a hydrogenation flask and suspended in 50 ml of ethanol. 7.6 g of 4'-chloro-2,2'-diethoxy-2'-nitroacetanilide are added thereto and the mixture is hydrogenated at room temperature and normal pressure. The uptake of hydrogen has finished after 2 hours. After suction filtration and concentration of the filtrate, the product is precipitated with water. There is obtained 4'-chloro-2,2-diethoxy-2'-aminoacetanilide of melting point 89°-90° C.

Workup

  1. customis hydrogenated at room temperature
  2. filtrationAfter suction filtration and concentration of the filtrate
  3. customthe product is precipitated with water

Sources & evidence

ORD record
ord-58fab68b9f434f7d80479eed8b844d08
Source dataset
uspto-grants-1986_04
Patent number
US04582526

Reaction notes

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