Phenyl Isothiocyanate → ST50557383

HRID 1380501Notes

Reaction equation

HRID 1380501 reaction equation
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:10]([NH:13][NH2:14])(=[O:12])[CH3:11]>C(O)C>[C:10]([NH:13][NH:14][C:8]([NH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[S:9])(=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 14039Acetohydrazide

Product 1

HCID 4191462ST50557383

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

On reacting 27 g of phenyl isothiocyanate and 15 g of acetylhydrazine in ethanol at room temperature, 1-acetyl-4-phenylthiosemicarbazide was formed. This 1-acetyl-4-phenylthiosemicarbazide was filtered off and heated under reflux in ethanol in the presence of sodium ethylate whereupon 3-mercapto-5-methyl-4-phenyl-1,2,4-triazole was formed.

Workup

  1. customat room temperature

Sources & evidence

ORD record
ord-419e2e63a7c540d6a833cbe772f089dc
Source dataset
uspto-grants-1986_04
Patent number
US04582775

Reaction notes

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