Hydrogen Bromide → HCID 178419525, compound

HRID 1380506Notes

Reaction equation

HRID 1380506 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([CH3:16])=[N:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:5][CH:4]=1.[BrH:17]>>[BrH:17].[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:10]([CH3:16])=[N:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 178488789HCID 178488789, compound

Product 1

HCID 178419525HCID 178419525, compound

Conditions

Temperature
0 °C

Procedure

1.5 g of 5-(4-methoxyphenyl)-4-methyl-2-(1H)-pyrimidinone are heated with 12.5 ml of 47% hydrobromic acid at 100° C. for 24 hours. The mixture is then cooled to 0° C., and the product which has crystallised out is filtered off with suction and washed with cold ethanol. 1.3 g of 5-(4-hydroxyphenyl)-4-methyl-2-(1H)-pyrimidinone hydrobromide are obtained. Melting point above 300° C.

Workup

  1. customthe product which has crystallised out
  2. filtrationis filtered off with suction
  3. washwashed with cold ethanol

Sources & evidence

ORD record
ord-f2971eb0248c49fe9f1aed946423aa8b
Source dataset
uspto-grants-1986_04
Patent number
US04582834

Reaction notes

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