Hydrochloric Acid → HCID 178488790, compound

HRID 1380509Notes

Reaction equation

HRID 1380509 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([CH3:16])=[N:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:5][CH:4]=1.[ClH:17].CCOCC>CO>[ClH:17].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:10]([CH3:16])=[N:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178488789HCID 178488789, compound

Product 1

HCID 178488790HCID 178488790, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.5 g of 5-(4-methoxyphenyl)-4-methyl-2-(1H)-pyrimidinone are dissolved in methanol, the solution is acidified with ethereal hydrochloric acid (pH 2-3), and ether is added to incipient opalescence. The solution is cooled and the crystals are filtered off with suction. After drying, 3.3 g of 5-(4-methoxyphenyl)-4-methyl-2-(1H)-pyrimidinone hydrochloride are obtained. Melting point 265° C. (decomposition).

Workup

  1. additionis added to incipient opalescence
  2. temperatureThe solution is cooled
  3. filtrationthe crystals are filtered off with suction
  4. customAfter drying

Sources & evidence

ORD record
ord-feecbc3565a14fa8abce4e12d79ec66e
Source dataset
uspto-grants-1986_04
Patent number
US04582834

Reaction notes

Loading…