Hydrazine hydrate (1:1) → HCID 178509165, compound

Participants

Reaction Steps

As for Example 3, a mixture of 66.0 g (0.3 moles) of benzyl N-piperazinecarboxylate and 43.8 g (0.3 moles) of dimethyl cyanodithioiminocarbonate in 300 ml of acetonitrile was refluxed for 16 hours. After cooling, filtration and washing, 16.0 ml (0.32 moles) of hydrazine hydrate was added to the filtrate and the mixture was refluxed for 4 hours. Cooling, filtration, and washing with cold acetonitrile, then hexane gave 74.7 g of the desired product as colorless crystals, mp 157°-159° C.

Provenance & Evidence