反应详情

Heat 126 g of the aldehyde of Step C in a mixture of 1500 ml of glacial acetic acid and 1500 ml of 48% hydrogen bromide in an oil bath at 150° C. with mechanical stirring until no trace of nondemethylated product remains (4-5 days). Cool the reaction mixture and pour into 7 liters of water. Separate the precipitate, wash well with water and dry in vacuo at 70° C. to constant weight. (Yield: 108.2 g).

1. custom(4-5 days)
2. temperatureCool the reaction mixture
3. customSeparate the precipitate
4. washwash well with water
5. customdry in vacuo at 70° C. to constant weight