Glycidol → N-{2-[(2,3-Dihydroxypropyl)amino]ethyl}-2-methylpropanamide

HRID 1380586노트

반응식

HRID 1380586 반응식
[CH:1]([C:4]([NH:6][CH2:7][CH2:8][NH2:9])=[O:5])([CH3:3])[CH3:2].[CH2:10]1[O:12][CH:11]1[CH2:13][OH:14]>C(O)(C)C>[CH3:2][CH:1]([C:4]([NH:6][CH2:7][CH2:8][NH:9][CH2:10][CH:11]([OH:12])[CH2:13][OH:14])=[O:5])[CH3:3]

참가 물질

4

반응물 2

HCID 11164GlycidolHCID 12681828N-(2-Aminoethyl)-2-methylpropanamide

생성물 1

HCID 14347794N-{2-[(2,3-Dihydroxypropyl)amino]ethyl}-2-methylpropanamide수율 30.4%

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
25 °C

실험 절차

To 39 g (0.3 mol) of 2-(isopropylcarbonylamino)ethylamine in 150 ml of isopropyl alcohol was added 22.2 g (0.3 mol) of glycidol. The reaction mixture was stirred at 25° C. for 24 hours and evaporated in vacuo. The residual oil was chromatographed (silica gel/ethanol) to give 18.6 g (30%) of product. This compound was identified by NMR and IR spectroscopy.

후처리

  1. customevaporated in vacuo
  2. customThe residual oil was chromatographed (silica gel/ethanol)

출처 및 근거

ORD 기록
ord-7b6c53e08e4f45b889f1b6cc40955944
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582855

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