Hydrogen Bromide → 1-Propanone, 2-bromo-2-methyl-1-[4-(methylthio)phenyl]-

HRID 1380595Notes

Reaction equation

HRID 1380595 reaction equation
[CH3:1][CH:2]([CH3:13])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[Br:14]Br.Br>C(Cl)(Cl)(Cl)Cl>[Br:14][C:2]([CH3:13])([CH3:1])[C:3]([C:5]1[CH:6]=[CH:7][C:8]([S:11][CH3:12])=[CH:9][CH:10]=1)=[O:4]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 8525392-Methyl-1-[4-(methylthio)phenyl]-1-propanone

Product 1

HCID 114599841-Propanone, 2-bromo-2-methyl-1-[4-(methylthio)phenyl]-

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent2×

Procedure

369.2 g (1.9 mols) of 2-methyl-1-[4-(methylthio)phenyl]-propan-1-one are dissolved in 400 ml of carbon tetrachloride. 303.7 g (1.9 mols) of bromine, diluted with 270 ml of carbon tetrachloride, are added dropwise slowly to this solution, with cooling, at room temperature. The dissolved HBr gas is then driven off by blowing with nitrogen. The solution is concentrated and is then reacted further as described below.

Workup

  1. additionare added dropwise slowly to this solution
  2. concentrationThe solution is concentrated
  3. customis then reacted further

Sources & evidence

ORD record
ord-c6bb410086254fa185ca1466c10363c1
Source dataset
uspto-grants-1986_04
Patent number
US04582862

Reaction notes

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