反应详情

温度

60 °C

A mixture of 30 mg (0.75 mmol) of powdered sodium hydroxide, 100 mg (0.59 mmol) of 1,2-dinitrobenzene, 155 mg (0.75 mmol) of 2,6-di-t-butylphenol, and 1.0 mL of dimethylsulfoxide was heated at 60° C. for 17 hours and poured into 10 mL of 1N HCl, and the resulting aqueous mixture was extracted with three 10 mL portions of diethyl ether. The ether layers were combined, dried over magnesium sulfate, and concentrated. Purification of the residue by preparative thin layer chromatography (tlc) afforded 206 mg of crude 2,6-di-t-butyl-4-(2-nitrophenyl)phenol.

1. extractionthe resulting aqueous mixture was extracted with three 10 mL portions of diethyl ether
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. customPurification of the residue by preparative thin layer chromatography (tlc)