Ethanol → Ethyl 3-methoxy-4-(7H-purin-8-yl)benzoate

HRID 1380741Notes

Reaction equation

HRID 1380741 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](N)=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1.[CH2:21]([OH:23])[CH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([O:23][CH2:21][CH3:22])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 132845313-Methoxy-4-(7H-purin-8-yl)benzamide

Product 1

HCID 13284533Ethyl 3-methoxy-4-(7H-purin-8-yl)benzoate

Procedure

A quantity of 0.42 gm of 8-(2'-methoxy-4'-chlorocarbonyl-phenyl)-purine hydrochloride (see Example 43) was refluxed in 30 ml of ethanol for 45 minutes. The solvent was evaporated off, and the residue was purified over a silica gel column [eluant: methylene chloride/ethanol (50:1 to 19:1)].

Workup

  1. customThe solvent was evaporated off
  2. customthe residue was purified over a silica gel column [eluant: methylene chloride/ethanol (50:1 to 19:1)]

Sources & evidence

ORD record
ord-441c04dd5d6a457d8d41d361bc4b29a7
Source dataset
uspto-grants-1986_04
Patent number
US04582837

Reaction notes

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