Hydrochloric Acid → 3-Methoxy-4-(7H-purin-8-yl)benzamide

HRID 1380742Notes

Reaction equation

HRID 1380742 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1.Cl.[OH-:21].[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:10])=[O:21])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 132845293-Methoxy-4-(7H-purin-8-yl)benzonitrile

Product 1

HCID 132845313-Methoxy-4-(7H-purin-8-yl)benzamide

Procedure

One gram of 8-(2'-methoxy-4'-cyano-phenyl)-purine was dissolved in 75 ml of 2N sodium hydroxide solution and refluxed for 15 minutes. Then, the mixture was acidified with hydrochloric acid, and the mixture precipitated was separated into its components by use of silica gel [eluant: methylene chloride/ethanol (7:3 to 1:1)].

Workup

  1. temperaturerefluxed for 15 minutes
  2. customthe mixture precipitated
  3. customwas separated into its components by use of silica gel [eluant: methylene chloride/ethanol (7:3 to 1:1)]

Sources & evidence

ORD record
ord-cb128f2b04994f23a022483e480031f5
Source dataset
uspto-grants-1986_04
Patent number
US04582837

Reaction notes

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