Dichloromethane → 1-(2-Oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3-phenylpiperidin-2-one

HRID 138075Notes

Reaction equation

HRID 138075 reaction equation
[CH:59]([N:60]([CH:61]([CH3:62])[CH3:63])[CH2:64][CH3:65])([CH3:66])[CH3:67].[Cl:68][CH2:69][Cl:70].[F:42][C:43]([c:44]1[cH:45][c:46]([CH2:47][N:48]2[CH2:49][CH2:50][NH:51][CH2:52][CH2:53]2)[cH:54][cH:55][cH:56]1)([F:57])[F:58].[O:1]=[C:2]1[N:3]([CH2:14][C:15](=[O:16])[OH:17])[CH2:4][CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[P-:18]([F:19])([F:20])([F:21])([F:22])([F:23])[F:24].[n:25]1([O:26][C:27]([N:28]([CH3:29])[CH3:30])=[N+:31]([CH3:32])[CH3:33])[c:34]2[n:35][cH:36][cH:37][cH:38][c:39]2[n:40][n:41]1>>[O:1]=[C:2]1[N:3]([CH2:14][C:15](=[O:17])[N:51]2[CH2:50][CH2:49][N:48]([CH2:47][c:46]3[cH:45][c:44]([C:43]([F:42])([F:57])[F:58])[cH:56][cH:55][cH:54]3)[CH2:53][CH2:52]2)[CH2:4][CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 20608551-(3-(Trifluoromethyl)benzyl)piperazineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 673587022-(2-Oxo-3-phenylpiperidin-1-yl)acetic acid

Product 1

HCID 673585061-(2-Oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3-phenylpiperidin-2-one

Sources & evidence

ORD record
ord-369efdaf4d844ce5953b36b163f33e41
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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