Methylamine → HCID 20184582, compound

HRID 1380766Notes

Reaction equation

HRID 1380766 reaction equation
C[O:2][C:3]([C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1)=O.[CH3:27][NH2:28]>>[CH3:27][NH:28][C:3]([C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1)=[O:2]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 20184489HCID 20184489, compound

Product 1

HCID 20184582HCID 20184582, compoundYield 67%

Procedure

One and one-half grams (4.0 mmol) of 5-methoxycarbonyl-2-(2'-methoxy-4'-methanesulfonylamino-phenyl)-benzimidazole and 10 ml of methylamine were heated for four hours to 120° C. in a steel canister. Then, excess methylamine was evaporated off, and the residue was dissolved in a small amount of water and neutralized with concentrated hydrochloric acid. After the solution was evaporated, the crude product obtained was purified by chromatography (150 gm of silica gel; eluant: methylene chloride with 10% ethanol).

Workup

  1. customThen, excess methylamine was evaporated off
  2. dissolutionthe residue was dissolved in a small amount of water and neutralized with concentrated hydrochloric acid
  3. customAfter the solution was evaporated

Sources & evidence

ORD record
ord-9f2fcd5777c1473da7d89946f2c114e8
Source dataset
uspto-grants-1986_04
Patent number
US04582837

Reaction notes

Loading…