反应详情

3.15 gms of t-butyl α-(1,2,4-triazol-1-yl)-β-hydroxy-β-(2,4-dichlorophenyl)propionate were added to 50 mls of chloroform along with 1.1 gms of 4-dimethylaminopyridine. 1.25 gms of propionyl chloride were then added to the system. The reaction mixture was then refluxed for 18 hours. The reaction solution was then first washed with aqueous 5 wt. % hydrochloric acid and then with aqueous sodium hydroxide. The organic phase was dried over sodium sulfate and then filtered. The filtrate was evaporated to dryness under vacuum affording 2.78 gms of the title compound as a yellow wax.

1. temperatureThe reaction mixture was then refluxed for 18 hours
2. washThe reaction solution was then first washed with aqueous 5 wt. % hydrochloric acid
3. dry with materialThe organic phase was dried over sodium sulfate
4. filtrationfiltered
5. customThe filtrate was evaporated to dryness under vacuum