Hydroxyamine hydrochloride → HCID 86740739, compound

HRID 1380818Notes

Reaction equation

HRID 1380818 reaction equation
[CH2:1]([CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]1=O)[CH2:2][CH:3]=[CH2:4].Cl.[NH2:17][OH:18].C([O-])(=O)C.[Na+]>CO>[CH2:1]([CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]1=[N:17][OH:18])[CH2:2][CH:3]=[CH2:4]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 11975884HCID 11975884, compound

Product 1

HCID 86740739HCID 86740739, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5.43 g of 1-(but-3-ene-yl)-2-tetralone, 54 ml of methanol, 2.06 g of hydroxylamine hydrochloride, and 2.41 g of sodium acetate was stirred and heated at reflux for 20 minutes. The reaction mixture was concentrated in vacuo to a small volume and the residue partitioned between ether and water. The ether layer was washed with sodium bicarbonate solution, dried over anhydrous magnesium sulfate, and concentrated to an oil, 5.78 g.

Workup

  1. temperatureheated
  2. temperatureat reflux for 20 minutes
  3. concentrationThe reaction mixture was concentrated in vacuo to a small volume
  4. customthe residue partitioned between ether and water
  5. washThe ether layer was washed with sodium bicarbonate solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated to an oil, 5.78 g

Sources & evidence

ORD record
ord-961fc9021b5d4cf7a541e10991268eb3
Source dataset
uspto-grants-1986_04
Patent number
US04584294

Reaction notes

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