Diethylamine → HCID 23324639, compound

HRID 1380838Notes

Reaction equation

HRID 1380838 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][Cl:11])[N:7]=[C:6](Cl)[N:5]=1)[CH3:2].[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14]>>[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([CH2:10][Cl:11])[N:7]=[C:6]([N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 23324619HCID 23324619, compound

Product 1

HCID 23324639HCID 23324639, compound

Procedure

4-Ethoxy-2-chloro-6-chloromethyl-pyrimidine (see Example 97) is reacted with diethylamine analogously to the process described in Example 98 in order to produce 4-ethoxy-6-chloromethyl-2-diethylamino-pyrimidine which is required as the starting material in Example 42. This product is obtained in the form of a yellow oil, 1H-NMR (CDCl3): 1.20 (t, N(CH2CH3)2), 1.37 (t, OCH2CH3), 3.60 (q, N(CH2CH3)2), 4.33 (s, CH2Cl), 4.35 (q, OCH2CH3), 6.06 (s, CH).

Sources & evidence

ORD record
ord-94741fa6868f4638b003612bf02695cd
Source dataset
uspto-grants-1986_04
Patent number
US04584295

Reaction notes

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