Sodium Hydroxide → HCID 23324631, compound

HRID 1380840Notes

Reaction equation

HRID 1380840 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([S:12][CH2:13][CH3:14])[N:9]=[C:8]([S:15][CH2:16][CH3:17])[N:7]=1)(=O)C.[OH-].[Na+]>C(O)C.C(OCC)C>[CH2:16]([S:15][C:8]1[N:7]=[C:6]([CH2:5][OH:4])[CH:11]=[C:10]([S:12][CH2:13][CH3:14])[N:9]=1)[CH3:17]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 23324667HCID 23324667, compound

Product 1

HCID 23324631HCID 23324631, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 3283Diethyl EtherSolvent

Procedure

A solution of 1.6 g (0.0059 mol) of 4-acetoxymethyl-2,6-diethylthio-pyrimidine in 3 ml of ethanol is treated at 0° C. with a solution of 0.86 g (0.0065 mol) of sodium hydroxide in 2.5 ml of ethanol. After 5 minutes the mixture is diluted with 150 ml of diethyl ether and washed neutral with water. The organic phase is dried over anhydrous magnesium sulphate and evaporated. In this manner there is obtained as the residue 2,6-diethylthio-4-hydroxymethyl-pyrimidine.

Workup

  1. washwashed neutral with water
  2. dry with materialThe organic phase is dried over anhydrous magnesium sulphate
  3. customevaporated

Sources & evidence

ORD record
ord-8870c4316cb2463991ff31d83ce3f4c8
Source dataset
uspto-grants-1986_04
Patent number
US04584295

Reaction notes

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