HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | n-(2,2-Dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide | HCID 13092500 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one | HCID 1482373 | — |
Reaction Steps
A solution of N-(2,2-dimethoxyethyl)-3,4-dimethoxyphenylacetamide (600.6 g) in concentrated hydrochloric acid (3 liters) is mixed with glacial acetic acid (3 liters). After it has been left to stand for 17 hours at ambient temperature the mixture is poured onto ice. The crystals precipitated are suction filtered, washed with water until neutral and then dried. Yield: 350 g. Mp: 234°-237° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584293 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-30992379adad4ff78db3b30b0fb777ac |
| Source note | uspto-grants-1986_04 |