反应详情

温度

30 °C

First, 3,4-dimethoxyphenylacetic acid (49.05 g, 0.25 mol) is added in batches to concentrated nitric acid (500 ml), with cooling, at 30° C. and stirred for a further 15 minutes with cooling. The reaction mixture is poured onto ice water (1.5 liters), the precipitate obtained is suction filtered, washed with ice water until neutral and dried. Yield: 56.4 g. Mp: 209°-211° C.

1. temperaturewith cooling
2. additionThe reaction mixture is poured onto ice water (1.5 liters)
3. customthe precipitate obtained
4. washwashed with ice water until neutral and
5. customdried