3-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → HCID 13579653, compound

HRID 1380886Notes

Reaction equation

HRID 1380886 reaction equation
[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14]Cl)[CH2:10][CH2:11][C:5]=2[CH:4]=1.[CH3:21][O:22][C:23]1[CH:32]=[C:31]2[C:26]([CH2:27][CH2:28][CH:29]([NH:33][CH3:34])[CH2:30]2)=[CH:25][CH:24]=1>C(N(CC)CC)C>[CH3:1][O:2][C:3]1[C:18]([O:19][CH3:20])=[CH:17][C:6]2[CH2:7][C:8](=[O:16])[N:9]([CH2:12][CH2:13][CH2:14][N:33]([CH3:34])[CH:29]3[CH2:28][CH2:27][C:26]4[C:31](=[CH:32][C:23]([O:22][CH3:21])=[CH:24][CH:25]=4)[CH2:30]3)[CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 130925103-(3-Chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-oneHCID 13579646HCID 13579646, compound

Product 1

HCID 13579653HCID 13579653, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound is prepared analogously to Example 1 by reacting 1-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-3-chloropropane, triethylamine and 7-methoxy-2-methylamino-1,2,3,4-tetrahydronaphthalene. Mp: 189°-190° C. (decomp.).

Sources & evidence

ORD record
ord-4080e2ea8c35483d99a818df0bc766c3
Source dataset
uspto-grants-1986_04
Patent number
US04584293

Reaction notes

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