反应详情

Here, 1-[7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(6,7-dimethoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-propane (1.64 g, 0.0034 mol) is added at 70° C. to a suspension of selenium dioxide (0.41 g, 0.0036 mol) and Celite (0.34 g) in 1,4-dioxan (17 ml) and water (0.68 ml) is added and the mixture is refluxed for 40 hours. After cooling, it is suction filtered, concentrated by rotary evaporation in vacuo and purified over silica gel (40 g) (32-63 μm) with methylene chloride and increasing amounts of ethanol (up to 40%). The clean fractions are concentrated by evaporation and the hydrochloride is precipitated from acetone. Yield: 0.6 g. Mp: >145° C. (decomp.).

1. temperaturethe mixture is refluxed for 40 hours
2. temperatureAfter cooling
3. filtrationfiltered
4. concentrationconcentrated by rotary evaporation in vacuo
5. custompurified over silica gel (40 g) (32-63 μm) with methylene chloride
6. temperatureincreasing amounts of ethanol (up to 40%)
7. concentrationThe clean fractions are concentrated by evaporation
8. customthe hydrochloride is precipitated from acetone