Hydrochloric Acid → HCID 23324906, compound

HRID 1380946Notes

Reaction equation

HRID 1380946 reaction equation
C[O:2][C:3](=[O:22])[CH2:4][CH2:5][CH:6]1[CH:10]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[CH2:9][C:8](=[O:21])[NH:7]1.C([O:25][C:26](=[O:45])[CH2:27][CH:28]([C:35]1[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:43])[F:42])=[CH:37][CH:36]=1)[CH:29]1[CH2:33][CH2:32][C:31](=[O:34])[NH:30]1)C.Cl>[OH-].[Na+]>[O:34]=[C:31]1[NH:30][CH:29]([CH:28]([C:35]2[CH:40]=[CH:39][C:38]([C:41]([F:44])([F:42])[F:43])=[CH:37][CH:36]=2)[CH2:27][C:26]([OH:45])=[O:25])[CH2:33][CH2:32]1.[O:21]=[C:8]1[NH:7][CH:6]([CH2:5][CH2:4][C:3]([OH:22])=[O:2])[CH:10]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=2)[CH2:9]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 53683498HCID 53683498, compoundHCID 54267983HCID 54267983, compound

Product 2

HCID 23324906HCID 23324906, compoundHCID 23324907HCID 23324907, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 93.4 g of 5-oxo-3-[4-(trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid methyl ester and 5-oxo-β-[4-(trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid ethyl ester in aqueous sodium hydroxide solution (1 N, 370 ml) is heated to 60° C. for four hours. Excess aqueous hydrochloric acid (1 N, 370 ml) is added and the solution is concentrated under reduced pressure to give 5-oxo-β-[4-(trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid and 5-oxo-3-[4-(trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid.

Workup

  1. concentrationthe solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-1e91d15eb1dc4ade976f10a75eab8b3d
Source dataset
uspto-grants-1986_04
Patent number
US04584313

Reaction notes

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