HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxypropanoyl chloride → HCID 14742901, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxypropanoyl chloride | HCID 92495 | — |
| Reactant | HCID 13653845 | HCID 13653845 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 14742901 | HCID 14742901 | 90% |
Reaction Steps
Ten grams of 1-benzyl-3-methyl-4-(2-fluoroanilino)piperidine of Example XXIII and 4.57 g of 2-methoxypropionyl chloride are mixed in dry tetrahydrofuran. After two weeks the solid product is filtered from the mixture and converted with 10% NaOH to the free base; 10 g of 1-benzyl-3-methyl-4-[N-(2-fluorophenyl)-2-methoxypropionamido]piperidine is obtained (90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04584303 |
| Source dataset | uspto-grants-1986_04 |
| ORD ID | ord-94f3aa703b0b45cbb134574064aca8dc |
| Source note | uspto-grants-1986_04 |