2-Methoxypropanoyl chloride → HCID 14742901, compound

HRID 1380962Notes

Reaction equation

HRID 1380962 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[CH:10]([CH3:22])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][O:24][CH:25]([CH3:29])[C:26](Cl)=[O:27]>O1CCCC1>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[C:26](=[O:27])[CH:25]([O:24][CH3:23])[CH3:29])[CH:10]([CH3:22])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 924952-Methoxypropanoyl chlorideHCID 13653845HCID 13653845, compound

Product 1

HCID 14742901HCID 14742901, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ten grams of 1-benzyl-3-methyl-4-(2-fluoroanilino)piperidine of Example XXIII and 4.57 g of 2-methoxypropionyl chloride are mixed in dry tetrahydrofuran. After two weeks the solid product is filtered from the mixture and converted with 10% NaOH to the free base; 10 g of 1-benzyl-3-methyl-4-[N-(2-fluorophenyl)-2-methoxypropionamido]piperidine is obtained (90% yield).

Workup

  1. filtrationAfter two weeks the solid product is filtered from the mixture

Sources & evidence

ORD record
ord-94f3aa703b0b45cbb134574064aca8dc
Source dataset
uspto-grants-1986_04
Patent number
US04584303

Reaction notes

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