huagongshe.com
HRID1381144

反应详情

EQUATION

反应方程式

HRID 1381144 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CN(CCCl)Cc1ccccc1.Cl
HCID12822620

N-Benzyl-2-chloro-N-methylethan-1-amine--hydrogen chloride (1/1)

C10H15Cl2N

结构：COc1ccc([C@@H]2Sc3cc(Cl)ccc3NC(=O)[C@@H]2O)cc1
HCID15593400

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc([C@@H]2Sc3cc(Cl)ccc3N(CCN(C)Cc3ccccc3)C(=O)[C@@H]2O)cc1
HCID70454776

未命名化合物

收率 114.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 9 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 7.7 g of 2-(N-benzyl-N-methylamino)ethyl chloride hydrochloride, 9.62 g of potassium carbonate and 600 ml of acetone is treated in the same manner as described in Example 4-(1). 14.8 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-benzyl-N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are obtained as an oil.

WORKUP

后处理

  1. additionis treated in the same manner