Potassium Carbonate → HCID 70454776, compound

HRID 1381144Notes

Reaction equation

HRID 1381144 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C@@H:15]([OH:16])[C:14](=[O:17])[NH:13][C:12]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:11]=3[S:10]2)=[CH:5][CH:4]=1.Cl.[CH2:24]([N:31]([CH2:33][CH2:34]Cl)[CH3:32])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C@@H:15]([OH:16])[C:14](=[O:17])[N:13]([CH2:34][CH2:33][N:31]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH3:32])[C:12]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:11]=3[S:10]2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 12822620N-(2-Chloroethyl)-N-methylbenzylamine hydrochlorideHCID 15593400HCID 15593400, compound

Product 1

HCID 70454776HCID 70454776, compoundYield 114.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 9 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 7.7 g of 2-(N-benzyl-N-methylamino)ethyl chloride hydrochloride, 9.62 g of potassium carbonate and 600 ml of acetone is treated in the same manner as described in Example 4-(1). 14.8 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-benzyl-N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one are obtained as an oil.

Workup

  1. additionis treated in the same manner

Sources & evidence

ORD record
ord-a9790d4631074ce9a3e05a8cedc4b840
Source dataset
uspto-grants-1986_04
Patent number
US04585768

Reaction notes

Loading…