Hydrochloric Acid → HCID 86740003, compound

HRID 1381162Notes

Reaction equation

HRID 1381162 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C@@:9]12[O:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[C@@H:10]1[CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2.C[S-].[Li+].Cl>CN(C)P(N(C)C)(N(C)C)=O.O>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C@@:9]12[O:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[C@@H:10]1[CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 11018798HCID 11018798, compoundHCID 86740004HCID 86740004, compound

Product 1

HCID 86740003HCID 86740003, compoundYield 79.5%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 12679HexamethylphosphoramideSolvent

Procedure

A mixture of 1.51 g of cis-1,2,3,4,4a,9b-hexahydro-4a-(2-methoxyphenyl)-2-methyl-benzofuro[3,2-c]pyridine and 1.56 g of lithium thiomethoxide in 13 ml of dry hexamethylphosphoramide was heated at 140° under a drying tube for 4 hours. The cooled reaction mixture was diluted with 150 ml of water and the pH adjusted to 7 by slow addition of 2N HCl with stirring. As the pH reached neutral, product started to precipitate out. The mixture was cooled to 0° and stirred for 30 minutes. The precipitated material was collected, washed with water and then a small amount of ether, and dried to afford 1.14 g (79.5%) of crystalline solid, m.p. s 178, 188°-191°. Recrystallization from ethanol gave 0.90 (62.7%) of colorless crystals, m.p. s 197, 197.5°-199°.

Workup

  1. temperaturewas heated at 140° under a drying tube for 4 hours
  2. customThe cooled reaction mixture
  3. customto precipitate out
  4. temperatureThe mixture was cooled to 0°
  5. stirringstirred for 30 minutes
  6. customThe precipitated material was collected
  7. washwashed with water
  8. dry with materiala small amount of ether, and dried

Sources & evidence

ORD record
ord-8375cd69b34047a2b032489e4d223225
Source dataset
uspto-grants-1986_04
Patent number
US04585779

Reaction notes

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