反应详情

38 Grams of methyl anthranilate and 35 g of potassium carbonate were dissolved in 300 ml of a mixture of acetone-water (2:1), then to this solution was added dropwise 30 g of chloroacetyl chloride under an ice-cooled condition with stirring. After completion of the addition, the reaction was carried out at a room temperature for 2 hours, then 200 ml of water was added to the reaction mixture, and the mixture obtained was ice-cooled, and the crystals precipitated were collected by filtration. The crystals collected were washed with water and ethanol, and recrystallized from methanol to obtain 48.6 g of methyl o-(α-chloroacetylamino)benzoate in the form of colorless needle-like crystals. Melting point: 97°-99° C.

1. temperaturecooled condition
2. additionAfter completion of the addition
3. customthe mixture obtained
4. temperaturecooled
5. customthe crystals precipitated
6. filtrationwere collected by filtration
7. customThe crystals collected
8. washwere washed with water and ethanol
9. customrecrystallized from methanol