反应详情

25 Grams of methyl o-methylaminobenzoate was dissolved in 125 ml of acetone, to this solution was added a solution prepared by dissolving 20.92 g of potassium carbonate in 60 ml of water. Under an ice-cooled condition, 17.95 g of chloroacetyl chloride was added dropwise thereto, then the reaction mixture was stired at a room temperature for 1 hour. Acetone was removed by distillation, the residue obtained was extracted with chloroform, then the chloroform layer was washed with water, dried and the solvent was removed by distillation. The residue thus obtained was purified by a silica gel column chromatography to obtain 16.80 g of N-methyl-o-methoxycarbonyl-α-chloroacetanilide in the form of colorless oily substance.

1. additionwas added a solution
2. customprepared
3. additionwas added dropwise
4. customAcetone was removed by distillation
5. customthe residue obtained
6. extractionwas extracted with chloroform
7. washthe chloroform layer was washed with water
8. customdried
9. customthe solvent was removed by distillation
10. customThe residue thus obtained
11. customwas purified by a silica gel column chromatography