反应详情

温度

50 °C

32 Grams of 4-(3,4-dimethoxybenzoyl)piperazine and 13.1 g of potassium hydroxide were dissolved in 300 ml of dimethylformamide (DMF), then under an ice-cooled condition with stirring, 10 g of α-chloroacetic acid was added thereto, next the reaction mixture was heated at 50° C. for 5 hours with stirring. After completion of the reaction, the reaction mixture was concentrated to dryness, the residue obtained was dissolved in water. The solution obtained was washed with chloroform, the aqueous layer was neutralized with concentrated hydrochloric acid, crystals formed were collected by filtration to obtain 9.8 g of α-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]acetic acid.

1. temperatureunder an ice-cooled condition
2. stirringwith stirring
3. customAfter completion of the reaction
4. concentrationthe reaction mixture was concentrated to dryness
5. customthe residue obtained
6. customThe solution obtained
7. washwas washed with chloroform
8. customformed
9. filtrationwere collected by filtration