Monobenzone → HCID 13320250, compound

HRID 1381230Notes

Reaction equation

HRID 1381230 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]2[O:13][CH:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([O:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1([CH2:14][O:21][C:22]2[CH:23]=[CH:24][C:25]([O:28][C@@H:11]3[CH2:12][N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH2:9][C@H:10]3[OH:13])=[CH:26][CH:27]=2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 7638MonobenzoneHCID 98153703-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane

Product 1

HCID 13320250HCID 13320250, compound

Procedure

A mixture of 40 g. of 1-benzyl-3,4-epoxypyrrolidine and 42 g. of 4-benzoxyphenol was heated at 130° C. for 8 hr. On cooling, the mixture crystallized. Three crystallizations from petroleum ether-cyclohexane gave fluffy white crystals melting at 98.0°-100.0° C. The yield was 6.0 g (8%).

Workup

  1. additionA mixture of 40 g
  2. temperatureOn cooling
  3. customthe mixture crystallized
  4. customThree crystallizations from petroleum ether-cyclohexane

Sources & evidence

ORD record
ord-7507ad96918c46bfa217b7c66e3653e6
Source dataset
uspto-grants-1986_04
Patent number
US04585785

Reaction notes

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