Styrene Oxide → HCID 23323903, compound

HRID 1381263Notes

Reaction equation

HRID 1381263 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[S:9][C:8]([C:10]([NH2:12])=[O:11])=[CH:7][CH:6]=1.[C:13]1([CH:19]2[O:21][CH2:20]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[OH:21][CH:19]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:20][N:1]([CH2:20][CH:19]([OH:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:2][CH2:3][CH2:4][C:5]1[S:9][C:8]([C:10]([NH2:12])=[O:11])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 7276Styrene OxideHCID 198091145-(3-Aminopropyl)thiophene-2-carboxamide

Product 1

HCID 23323903HCID 23323903, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

750 mg of 5-(3-aminopropyl)-2-thiophenecarboxamide and 0.47 ml of (±)-phenylethylene oxide were heated to boiling for 4 hours in 4.7 ml of ethanol. After evaporation of the solvent in vacuo, the residue was chromatographed on silica gel with ether/methanol. There were obtained 400 mg of 5-[3-[bis-(β-hydroxyphenethyl)amino]propyl]-2-thiophenecarboxamide; UV: ε277 =11250.

Workup

  1. customAfter evaporation of the solvent in vacuo
  2. customthe residue was chromatographed on silica gel with ether/methanol

Sources & evidence

ORD record
ord-017e18e97efb43a9a02ff1d06ec21c62
Source dataset
uspto-grants-1986_04
Patent number
US04585796

Reaction notes

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