Potassium Carbonate → Ethyl 1-methylpyrrolidine-3-carboxylate

HRID 1381279Notes

Reaction equation

S(Cl)(Cl)=O.O[CH:6]1[CH2:10][N:9]([CH3:11])[CH2:8][CH:7]1[C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+]>>[CH3:11][N:9]1[CH2:10][CH2:6][CH:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:8]1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 24386Thionyl Chloride

HCID 23323991HCID 23323991, compound

Product 1

HCID 21202735Ethyl 1-methylpyrrolidine-3-carboxylate

Procedure

The ethyl 1-methyl-3-pyrrolidinecarboxylate was prepared by the reaction of thionyl chloride with ethyl 4-hydroxy-1-methyl-3-pyrrolidinecarboxylate followed by basifying with potassium carbonate.

Sources & evidence

ORD record: ord-2bd84c45dfbb409bb693635a799aaa20
Source dataset: uspto-grants-1986_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04585865

Reaction notes

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