Hydrogen Bromide → 1-Methyl-3-bromopropyldiethylamine hydrobromide

HRID 1381302Notes

Reaction equation

HRID 1381302 reaction equation
[CH3:1][CH:2]([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:17]>C(Cl)(Cl)Cl>[BrH:17].[CH3:1][CH:2]([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH2:3][CH2:4][Br:17]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 135201021-Methyl-3-phenoxypropyldiethylamine

Product 1

HCID 201358451-Methyl-3-bromopropyldiethylamine hydrobromideYield 78%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5 g of the 1-methyl-3-phenoxypropyldiethylamine was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled, 20 ml of chloroform and was added and then the solution was separated into two phases, which phases were then separated from each other. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.88 g of 1-methyl-3-bromopropyldiethylamine hydrobromide in a yield of 78%.

Workup

  1. temperatureThe reaction solution was cooled
  2. customthe solution was separated into two phases, which phases
  3. customwere then separated from each other
  4. customThe hydrobromic acid was removed under reduced pressure
  5. customthe residue was recrystallized from 5 ml of ethyl alcohol

Sources & evidence

ORD record
ord-350da2d3fb74443bafb9d21ef2ba962a
Source dataset
uspto-grants-1986_04
Patent number
US04585869

Reaction notes

Loading…